Introduction to Cell Mechanics and MechanobiologyIntroduction to Cell Mechanics and Mechanobiology



Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical ...

Author: Christopher R. Jacobs

Publisher: Garland Science

ISBN: 9781135042653

Category:

Page: 350

View: 180

Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical prope

Mechanics of the CellMechanics of the Cell



New edition exploring the mechanical features of biological cells for advanced undergraduate and graduate students in physics and biomedical engineering.

Author: David Boal

Publisher: Cambridge University Press

ISBN: 9780521113762

Category:

Page: 608

View: 973

New edition exploring the mechanical features of biological cells for advanced undergraduate and graduate students in physics and biomedical engineering.

Cell MechanicsCell Mechanics



Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more.

Author: Arnaud Chauvière

Publisher: CRC Press

ISBN: 1420094556

Category:

Page: 482

View: 194

Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior of cells, specifically tumor cells. In the first part of the text, the book discusses the powerful tool of microrheology for investigating cell mechanical properties, multiphysics and multiscale approaches for studying intracellular mechanisms in cell motility, and the role of subcellular effects involving certain genes for inducing cell motility in cancer. Focusing on models based on physical, mathematical, and computational approaches, the second section develops tools for describing the complex interplay of cell adhesion molecules and the dynamic evolution of the cell cytoskeleton. The third part explores cell interactions with the environment, particularly the role of external mechanical forces and their effects on cell behavior. The final part presents innovative models of multicellular systems for developmental biology, cancer, and embryogenesis. This book collects novel methods to apply to cells and tissues through a multiscale approach. It presents numerous existing tools while stimulating the discovery of new approaches that can lead to more effective and accurate predictions of pathologies.

Cell and Matrix MechanicsCell and Matrix Mechanics



This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forc

Author: Roland Kaunas

Publisher: CRC Press

ISBN: 9781466553828

Category:

Page: 376

View: 299

Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell–cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.

Cell MechanicsCell Mechanics



As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the ...

Author: Yu-Li Wang

Publisher: Academic Press

ISBN: 0080548709

Category:

Page: 632

View: 475

Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions Includes highly significant topics relevant to basic and translational research, as well as tissue engineering Emphasizes mechanical input and output of cells

Advances in Cell MechanicsAdvances in Cell Mechanics



The book is intended for researchers and graduate students working in the fields of molecular cell biology, bio-engineering and bio-mechanics, soft matter physics, computational mechanics, bio-chemistry and bio-medicine.

Author: Shaofan Li

Publisher: Springer Science & Business Media

ISBN: 9783642175909

Category:

Page: 316

View: 854

"Advances in Cell Mechanics" presents the latest developments in cell mechanics and biophysics, mainly focusing on interdisciplinary research in cell biology and the biophysics of cells. Moreover, a unique feature of the book is its emphasis on the molecular and complex continuum modeling and simulations of the cells. It may be the first work that brings rigorous and quantitative scientific analysis and state-of-the-art simulation technology into cell biology research. The book is intended for researchers and graduate students working in the fields of molecular cell biology, bio-engineering and bio-mechanics, soft matter physics, computational mechanics, bio-chemistry and bio-medicine. All contributors are leading scholars in their respective fields. Dr. Shaofan Li is a professor and an expert for computational mechanics at the University of California-Berkeley, USA; Dr. Bohua Sun is a professor at Cape Peninsula University of Technology, South Africa.

Measuring Cell MechanicsMeasuring Cell Mechanics



Our particular aim here is to present the reader with an introduction to the primary tools used to measure these mechanical interactions and the material properties of cells that result from them.

Author: Margaret Gardel

Publisher: Biota Publishing

ISBN: 9781615046997

Category:

Page: 74

View: 140

Cells are inherently physical entities that both experience mechanical forces from their external environment and generate their own internal forces to drive cell motion. Our particular aim here is to present the reader with an introduction to the primary tools used to measure these mechanical interactions and the material properties of cells that result from them. These approaches can be applied to a diverse array of physiological processes and systems, providing important insight into the regulatory roles of mechanical interactions in cells. We cover techniques at both the molecular and cellular scales, including those that actively and passively probe the system. Along the way we cover the fundamental principles of each approach, while emphasizing the relevant length and timescales, along with the typical magnitudes of the measurements that can be made. Each section ends by highlighting uses of the various techniques in recent relevant publications, illustrating the exciting future of cell mechanics in quantitative cell biology research.

Cell Mechanics and Cellular EngineeringCell Mechanics and Cellular Engineering



This definition is derived from one developed for tissue engineering at a 1988 NSF workshop. The reader of this volume will see the definition being applied and stretched to study cell and tissue structure-function relationships.

Author: Van C. Mow

Publisher: Springer Science & Business Media

ISBN: 9781461384250

Category:

Page: 564

View: 444

Cell mechanics and cellular engineering may be defined as the application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological cells and the development of biological substitutes to restore cellular functions. This definition is derived from one developed for tissue engineering at a 1988 NSF workshop. The reader of this volume will see the definition being applied and stretched to study cell and tissue structure-function relationships. The best way to define a field is really to let the investigators describe their areas of study. Perhaps cell mechanics could be compartmentalized by remembering how some of the earliest thinkers wrote about the effects of mechanics on growth. As early as 1638, Galileo hypothesized that gravity and of living mechanical forces place limits on the growth and architecture organisms. It seems only fitting that Robert Hooke, who gave us Hooke's law of elasticity, also gave us the word "cell" in his 1665 text, Micrographid, to designate these elementary entities of life. Julius Wolffs 1899 treatise on the function and form of the trabecular architecture provided an incisive example of the relationship between the structure of the body and the mechanical load it bears. In 1917, D' Arcy Thompson's On Growth and Form revolutionized the analysis of biological processes by introducing cogent physical explanations of the relationships between the structure and function of cells and organisms.

Mechanics of the CellMechanics of the Cell



This second edition has been greatly updated and expanded, with new chapters on complex filaments, the cell division cycle, the mechanisms of control and organization in the cell, and fluctuation phenomena.

Author: David Boal

Publisher: Cambridge University Press

ISBN: 0521130697

Category:

Page: 622

View: 472

Exploring the mechanical features of biological cells, including their architecture and stability, this textbook is a pedagogical introduction to the interdisciplinary fields of cell mechanics and soft matter physics from both experimental and theoretical perspectives. This second edition has been greatly updated and expanded, with new chapters on complex filaments, the cell division cycle, the mechanisms of control and organization in the cell, and fluctuation phenomena. The textbook is now in full color which enhances the diagrams and allows the inclusion of new microscopy images. With around 280 end-of-chapter exercises exploring further applications, this textbook is ideal for advanced undergraduate and graduate students in physics and biomedical engineering. A website hosted by the author contains extra support material, diagrams and lecture notes, and is available at www.cambridge.org/Boal.

Cell Mechanics And Tumor DevelopmentCell Mechanics And Tumor Development



The focus of this book is on centrioles — small organelles adjacent to the nucleus in all human and animal (eucaryotic) cells.

Author: Ronald L Huston

Publisher: World Scientific

ISBN: 9789811208966

Category:

Page: 460

View: 944

The focus of this book is on centrioles — small organelles adjacent to the nucleus in all human and animal (eucaryotic) cells. It provides the findings and critical analyses of over 750 articles written in this century.In addition to centrioles, the topics include: centrosomes, chromosomes, microtubules and kinetochores, cell division and duplication, and tumor development. The book also includes discussions on centriole dynamics and electromagnetics effects. It concludes with a chapter on centriole errors — particularly cells with supernumerary centrioles.The book is intended for students, scholars, and researchers studying and working in the field of nuclear mechanics. In addition to the book content, it provides a guide for literature investigation.

Biomechanics of Cell DivisionBiomechanics of Cell Division



However, a review of the journals, books and conference proceedings related to various aspects of cytology reveals that mechanicians have not yet entered the field of cytology at a noticeable level.

Author: Nuri Akkas

Publisher: Springer Science & Business Media

ISBN: 9781468412710

Category:

Page: 374

View: 562

There are virtually hundreds of life scientists publishing hundreds of papers a year on numerous aspects of the cell cycle. The following are few of the topics covered: cell membrane organization, membrane components, cytoskeleton and associated proteins, cell motility, actin in dividing cells, surface modulating assemblies, microfilaments, microtubules, cleavage furrow, fusion, etc. In all these topics, lifescientists talk about, among others, the forces within the system, the motion within the system and the failure of the system. The concepts of force, motion and failure are, one way or another, all related to the structure of the cell and to the mechanics of the cell activities. When the concepts of mechanics and structure enter the problem then one has to talk about biomechanics; in this case, biomechanics of cytology which we would like to call "Cytbmechanics". However, a review of the journals, books and conference proceedings related to various aspects of cytology reveals that mechanicians have not yet entered the field of cytology at a noticeable level. Some lifescientists have indeed made use of the general principles of mechanics in their works; however, no truly interdisciplinary publication has yet appeared from the collaboration of mechanicians and lifescientists in the field of, for instance, cell division.

Computational Blood Cell MechanicsComputational Blood Cell Mechanics



The text presents a step-by-step approach to cell model building that can be adopted when developing and validating models for biomedical applications, such as filtering and sorting cells, or examining flow and deformations of individual ...

Author: Ivan Cimrak

Publisher: CRC Press

ISBN: 9781351378666

Category:

Page: 268

View: 766

Simulating blood cells for biomedical applications is a challenging goal. Whether you want to investigate blood flow behavior on the cell scale, or use a blood cell model for fast computational prototyping in microfluidics, Computational Blood Cell Mechanics will help you get started, and show you the path forward. The text presents a step-by-step approach to cell model building that can be adopted when developing and validating models for biomedical applications, such as filtering and sorting cells, or examining flow and deformations of individual cells under various conditions. It starts with basic building-blocks that, together, model the red blood cell membrane according to its physical properties, before moving on to discuss several issues that may pose problems along the way, and finally leads to suggestions on how to set up computational experiments. More details available at www.compbloodcell.eu

Nano and Cell MechanicsNano and Cell Mechanics



As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book.

Author: Horacio D. Espinosa

Publisher: John Wiley & Sons

ISBN: 9781118482599

Category:

Page: 520

View: 329

Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book. Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. Key features: • Provides an overview of recent advances in nano and cell mechanics. • Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena. • Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. • Presents multiscale-multiphysics modeling and experimentation techniques. • Examines applications in materials, manufacturing, electronics, medicine and healthcare. Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics.