This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism.
Author: Ala F. Nassar
A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.
Specific Factors which Can Influence Drug Metabolism Stereoselectivity in Drug
Metabolism In view of the fact that the majority of chiral synthetic or semisynthetic
drugs are marketed as racemates, consideration must be given to the potential ...
Author: Wolfgang A. Ritschel
Publisher: Amer Pharmacists Assn
A user-friendly handbook on the principles and techniques involved in the various applications of pharmacokinetics. Provides a concise reference for clinicians who need quick information on the pharmacokinetic characteristics of specific drugs. Thoroughly updated and revised, this book features pharmacokinetic data profiles on more than 600 drugs.
Fundamental to an understanding of pharmacokinetics is the role of the inherent
physicochemical properties of a molecule for it is these properties, in combination
with the nature of the physiological processes that handle the drug in the body, ...
Author: Gary Evans
Publisher: CRC Press
Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.
Treatment with certain drugs such as methylcholanthren (MC) and phenobar-
bital can increase metabolizing enzyme levels in the intestine. Enzyme induction
requires 2-4 days and is more extensive when the inducer is administered orally
Author: Younggil Kwon
Publisher: Springer Science & Business Media
This volume is a handbook primarily designed for scientists andtechnicians without formal pharmacokinetics/pharmacodynamics (PK/PD)training, who work in an industrial setting. The book is a primarydesktop reference and contains easy-to-understand guidance for PK/PDissues, study design, and data interpretation. PK/PD are integralaspects for investigating the disposition and pharmacological efficacyof drugs under various experimental and clinical conditions.
Author: Paul G. Pearson
Publisher: CRC Press
The second edition of a bestseller, this book presents the latest innovative research methods that help break new ground by applying patterns, reuse, and design science to research. The book relies on familiar patterns to provide the solid fundamentals of various research philosophies and techniques as touchstones that demonstrate how to innovate research methods. Filled with practical examples of applying patterns to IT research with an emphasis on reusing research activities to save time and money, this book describes design science research in relation to other information systems research paradigms such as positivist and interpretivist research.
date , inhibit metabolism of tricyclic antidepressants , thereby increasing both
tricyclic serum concentration and therapeutic response . Cimetidine and
fluoxetine inhibit cytochrome P - 450 - mediated hepatic drug oxidation , thereby
Author: Jerrold G. Bernstein
Publisher: Mosby Incorporated
(2E 1988) Discusses receptors drugs & neurotransmitters/ antianxiety agents & hypnotics/electroconvulsive therapy/etc
Drug name Combination drug Adulterant - excipient Heroin Phenacetin , aspirin ,
caffeine Lactose , mannitol , quinine ... name , chemical HANDBOOK OF DRUG
ANALYSIS Look-Alike and Designer Drugs Biological Samples Drug Metabolism.
Author: Ray H. Liu
Publisher: Amer Chemical Society
Covers preliminary test and chromatographic methods in forensic drug testing. Reviews identification methods such as molecular spectrophotometry, nuclear magnetic resonance, and mass spectrometry. Discusses the fundamental relationship between instrumentation and drug analysis. Evaluates the characteristics and pretreatment approaches for common sample categories. Presents in-depth test result interpretation on issues commonly encountered in workplace drug urinalysis. Analyzes and compares performance characteristics of immunoassays commonly used for workplace drug urinalysis.
The liver is most often the organ responsible for drug metabolism , while in most
cases the kidney is responsible for drug elimination . The majority of drug
metabolism is catalyzed by enzymes contained in the microsomes of hepatocytes
Author: Larry Bauer
Publisher: McGraw-Hill Medical
Designed for pharmacists and clinicians responsible for adjusting drug dosages based on the patient blood serum concentrations and other parameters, this indispensable, portable reference offers a variety of ways to perform pharmacokinetic calculations. Features calculation methods, algorithms for choosing the best calculation method, and case studies.
Almira M . Drug biotransformation . In , Katzung BG , ed . Basic and clinical
pharmacology . Norwalk , CT : Appleton & Lange ; 1992 : 49 - 59 . 2 . Watkins PB
. Role of cytochromes P450 in drug metabolism and hepatotoxicity . Semin Liver
Author: Philip O. Anderson
Publisher: Prentice Hall
Each drug monograph contains generic drug name, pharmacology, administration and adult dosage, special populations, dosage forms, patient instructions, pharmacokinetcis, adverse reactions, contraindications, precautions, drug interactions, parameters to monitor, and notes. Clinically relevant drug information relates to specific interactions, disease states, special populations, medical emergencies and nutrition support.